新技术帮助医生定位肿瘤位置

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作者：yangtao2014-4-14 7:23:33

2014年4月14日讯  --一直以来科学家都在寻找新的方法来定位肿瘤的位置。长期以来医生主要利用放疗、化疗或者切除的方法来定位并除去肿瘤。然而放疗和化疗具有极大的副作用，手术切除则一方面会破坏机体健康组织，另一方面残留的肿瘤细胞往往会留在体内，造成肿瘤的复发。
现在美国的研究人员开发出一种强大的眼镜，能够使佩戴的医生实时区分健康细胞和癌细胞。发明人Dr Ryan Fields介绍这项技术首先要在手术前，向患者注入一种能够与癌症细胞特异性结合的小肽，这种小肽能够释放出特定波长的荧光，虽然肉眼无法观察到，但却可以被眼镜上的传感器识别到，进而帮助医生确定癌症区域。虽然这项技术刚刚被提出来还处于早期研究的阶段但其前景是毋庸置疑的。一旦这项技术投入使用，今后癌症病人手术的规模将会大大减小，患者所受的损伤也会降低许多。目前在研究中，这一技术仅仅被用于治疗乳腺癌和皮肤癌，但是Dr Ryan Fields表示有信心将其推广到其他多种实体瘤治疗上去。详细英文报道：
Scientists are continually seeking new ways of targeting cancer - and the latest is high-tech goggles.
Currently doctors treating cancer have two main approaches - bombard the tumour with drugs and radiotherapy or cut it out.
The second option is very common but not always successful - because it is often also impossible to tell where the tumour ends and healthy tissue begins.
To try and combat this surgeons often remove tissue surrounding the tumour, but cancerous cells often remain, necessitating further surgery.
But a new goggle technology being developed in the US lets surgeons "see" which cells are cancerous and which are healthy, increasing the chances that they will be able remove all cancer cells in one operation.
"The technology is quite amazing - almost like having a microscope to guide your surgery in the operating room," says Dr Ryan Fields, a surgeon involved in a pilot study of the device.
'Seeing' cancer
In the study, patients are being injected with a dye before their surgery. The dye has a peptide - a small protein - attached to it that allows it to seek out and bind specifically to cancer cells.
The dyed cancer cells emit light at a wavelength that cannot be seen by the human eye, but can be detected by a sensor in the goggles worn by the surgeons.
"The sensor captures the fluorescence from the dye lodged in cancer tissue and projects the image into the surgeon's [field of] view," explained Dr Achilefu.
"This creates an augmented reality that allows the surgeons to see cancer cells glowing, providing real-time guidance during surgery.
It's early days but surgeons think that this technology is promising.
"It has the potential to reduce the size of operations, when safe, and guide us to take out more tissue, when required," said Dr Ryan Fields, a surgeon at Siteman Cancer Center at Barnes-Jewish Hospital.
It is estimated that up to 40% of breast cancer patients in the US, and just under 20% in the UK, require secondary surgery.
Being able to take a more strategic, precise approach to removing tumours could reduce the need for patients to undergo further stressful procedures.
Surgical precision
So far this new goggle technology has only been trialled on patients suffering from skin and breast cancer.
But Dr Achilefu is confident it can be used for different types of cancer. The dye has been shown to bind to breast, prostate, lung, colon pancreatic cancers, among others. It has even been shown to detect pre-cancerous cells.
These goggles are bringing instant tumour imaging to the operating room. But they aren't the only technology that is helping to improve the accuracy of tumour removal.
Elsewhere, other researchers have modified a surgical knife that uses heat to cut through tissue so it can instantly analyse whether the tissue the surgeon is cutting through is cancerous or healthy.
Smoke released when the heated blade cuts through tissue is sucked into a device that 'sniffs' it, analysing whether it is cancerous or healthy - allowing the surgeons to find the edges of the tumour and remove it with greater precision.
The true test of Dr Achilefu's goggles will be a large trial involving many hospitals.
"This type of technology certainly shows promise,' said Mr Tim Underwood, Senior Lecturer and Honorary Consultant Surgeon at University of Southampton, UK.
But he also cautions that, "All of these [new] technologies need much larger trials to prove their worth before they can be considered for routine use."